Abstract: In this research, the results of the effects of vincamine hydrochloride and pyrozalin iodide alkaloids on the relaxation of aortic smooth muscle cells in the presence of Ca2+ L-channels have been reported. The isometric contraction activity of the aortic blood vessel smooth muscle derived from rabbits was studied using mechanography. The results, under in vitro conditions, demonstrated that the contraction activity of the rabbit aortic blood vessel smooth muscle preparation induced by 50 mM KCl was dependent on the potential of the plasma membrane, associated with the activity of the Ca2*L-channels. It was found that vincamine and pyrozalin iodide alkaloids affected the blockage of the Ca2+i-channels and a reduction in [Ca2*] concentration. The obtained results suggest that the relaxing effect of vincamine hydrochloride and pyrozalin iodide alkaloids is based on the blockage of the L-type Ca2+ channels, and they also affect the receptor-operated Ca2+ channels. In conclusion, the results indicate that in providing the relaxing effect of vincamine and pyrozalin iodide alkaloids, the blockage of potential-dependent L-type Ca2t channels, along with the blockage of receptor-operated Ca2+ channels plays an important role.
The works show that, using fluorescent probes, it was used to study the effect of PC-8 on changes in the dynamics of the intracellular Ca2+ content in synaptosomes of the rat brain, depending on the site of the binding of glutamate on calcium channels by a specific mediator with glutamate. To measure the amount of cytosolic Ca2+ synaptosomes, we calculated using the Grinkevich equation. It has been shown that polyphenol PC-8 binds to the glutamate-binding site of NMDA receptors, so that the conductance for Ca2+ ions is reduced through a channel blocking the effect of polyphenol PC-8 can be explained. due to its binding to the competing action of the site, the binding of glutamate to NMDA receptors.
The mechanism of action of the alkaloid 1-(2´-bromine-4´,5´-dimethoxyphenyl) - 6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline (F-18) on the functional activity of smooth muscle cells of the rat aorta was studied. Isometric contraction activity was recorded using a Grass FT – 03 (Grass Instrument, USA) mechanotron. The relaxant effect of the F-18 alkaloid was found to be associated with blockade of Ca2 + (IP3R) channels in the SR, along with voltage- dependent and receptor-operated Ca2+channels in the aorta smooth muscle cell plasmalemma.
В данной статье проводится клинико-неврологические и биохимические методы исследования у больных детей с наследственной мотосенсорной нейропатии. Известно, что некоторые микроэлементы (Са2+, Mg2+, P5+) характеризуются высокой энергоемкостью и обладают высокой проникающей способностью в тела нейронов через лигандопосредованные рецепторы и сайты для кооперации данных микроэлементов. На фоне патогенетической терапии и физиотерапевтических реабилитационных мероприятий возможно ограничение степени тяжести наследственной мотосенсорной нейропатии, что особенно актуально в педиатрической неврологии.
В данной статье исследовано влияние йодида и перхлората калия, как в отдельности, так и при их совместном введении, на параметры, характеризующие секрецию тиреоидных гормонов. Изучались такие показатели, какуровень циклического аденозинмонофосфата (цАМФ) в ткани железы и количество внутриклеточных капель коллоида в условиях стимуляции тиреотропным гормоном.